A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in MiceVirion 기반 조합 백신은 쥐의 인플루엔자 및 SARS-CoV-2 질병으로부터 보호합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration antigenic antigenic drift approach boost immunity breadth combination vaccine Coronaviruses disease distribution domain elicited generate Genetic IAV immunogenic incorporation independent Influenza influenza A influenza A virus influenza vaccine influenza vaccines influenza vaccines. Influenza virus influenza virus influenza viruses Longevity mice Neutralizing antibodies neutralizing antibody New pandemic Particles pathogen Pathogens platform Protein provided respiratory respiratory virus respiratory viruses robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants Seasonal influenza shown the SARS-CoV-2 vaccination Vaccine vaccine production Vaccines variant virus viruses [DOI] 10.1128/jvi.00689-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregationSARS-CoV-2는 스트레스 과립의 분해를 손상시키고 ALS 관련 아밀로이드 응집을 촉진합니다Article Published on 2022-08-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 addition aggregation bind Cell cells cellular clearance experiment FUS Host host cells impair in vitro incorporation increased risk indicate infect Infection interactions Invasion mammalian cell mammalian cells Mutation N protein neurodegeneration NMR non-specific nucleocapsid nucleocapsid protein occur phase transition promote Protein Proteins reported SARS-CoV-2 SARS-COV-2 infection scenario stimulated Stress stress granule stress granule. stress granules [DOI] 10.1007/s13238-022-00905-7 PMC 바로가기 [Article Type] Article
Silent Antibodies Start Talking: Enhanced Lateral Flow Serodiagnosis with Two-Stage Incorporation of Labels into Immune ComplexesSilent Antibodies Start Talking: 면역 복합체에 라벨을 2단계 통합하여 향상된 측면 흐름 혈청 진단Article Published on 2022-06-212022-09-11 Journal: Biosensors [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] added antibody Antigen applied approach binding Blood carried coloration Complexes conjugate coronavirus COVID-19 demonstrated diagnostic diagnostic sensitivity diagnostic specificity enhanced false-negative false-negative results first stage Flow gold Gold nanoparticle Immune complexes immunochromatographic immunochromatography Immunoglobulin immunoglobulins incorporation increase in intensity lAbel Lateral lateral flow immunoassay LFIA magnitude membrane non-specific pathogen pathogen-specific Protein protein A RBD RBD protein recombinant RBD protein reduction risk SARS-CoV-2 separated serodiagnostic specific antibodies specificity staphylococcal test strip test strips. The diagnostic sensitivity variant zone [DOI] 10.3390/bios12070434 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 replication complex elongation and proofreading activitySARS-CoV-2 복제 복합체 신장 및 교정 활성의 특성화Article Published on 2022-06-102022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral base pairs biochemical characterization complex coronavirus Critical dATP degrade drug elongation exonuclease experiment feature genomic sequence groups highlight incorporation inefficient inhibitor Mutation nsp10 nsp14 nucleotide nucleotides oligonucleotide promote Proofreading RdRP reduced Replication resulting ribose RNA RNA-dependent RNA polymerase RNA-dependent RNA polymerases SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication sequence shown target the SARS-CoV-2 Viral protein [DOI] 10.1038/s41598-022-13380-1 PMC 바로가기 [Article Type] Article
Insight towards the effect of the multi basic cleavage site of SARS-CoV-2 spike protein on cellular proteasesArticle Published on 2022-06-062022-11-01 Journal: Virus research [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome Amino acid amino acid substitution Analysis analyzed Antiviral approach binding cathepsin B cell receptor cellular cellular protease cellular proteases cleavage site cleaving coronavirus coronavirus pathogenesis develop domain functional furin furin cleavage site generate Health help Host host cell protease host protease host range incorporation indicated Infection inhibitor insight Interaction involved maturation MD simulation MD simulations molecular molecular docking multi Mutation plasmin polybasic primary determinant protease Protein proteolytic activation Receptor binding S protein S1 and S2 SARS-CoV-2 SARS-CoV-2 spike protein shown spike Spike protein Spread subunits the S protein tissue tropism [DOI] 10.1016/j.virusres.2022.198845 PMC 바로가기 [Article Type] Article
Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein더 작고, 더 강하고, 더 안정적: SARS-CoV-2 중화 미니단백질의 펩타이드 변이체Article Published on 2022-06-042022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] amino acids antiviral activity approach breadth characterized complex de novo Degradation dissect full-length IMPROVE incorporation miniprotein Modification Mutation neutralization Neutralizing neutralizing capacity non-proteinogenic amino acids peptide peptide mimics peptides potency protein expression proteolytic RBD Receptor binding domain Recombinant protein reported resulting retained SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant Smaller Spike protein stability strength structure-based design susceptibility synthetic peptides the RBD the SARS-CoV-2 therapy variant virus virus variant virus. VoC [DOI] 10.3390/ijms23116309 PMC 바로가기 [Article Type] Article
SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5SARS-CoV-2 ORF7a는 숙주 인자 SERINC5의 항바이러스 효과를 강력하게 억제합니다Article Published on 2022-05-262022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome coronavirus Antiviral effect biogenesis Cell fusion cellular coronavirus 2 counteract evaluated expressed Factor HIV Host Human Human immunodeficiency virus immunodeficiency virus incorporation information inhibit involved ORF7a Protein respiratory restrict retroviruses SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SERINC5 Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sphingolipid transmembrane protein turn virion virions virus infectivity while [DOI] 10.1038/s41467-022-30609-9 PMC 바로가기 [Article Type] Article
Target-triggered cascade signal amplification for sensitive electrochemical detection of SARS-CoV-2 with clinical application임상 적용과 함께 SARS-CoV-2의 민감한 전기화학적 검출을 위한 표적 트리거 캐스케이드 신호 증폭Article Published on 2022-05-222022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis applied cascade Cascade signal amplification catalytic catalyzed clinical sample clinical samples complex coronavirus COVID-19 COVID-19 diagnosis Detection limit diagnosis of COVID-19 disease DNA early stage effective electrochemical biosensor electrostatic interaction generate Health high stability incorporation Interference linear Lower outbreak Pandemics Prevent random RNA Saliva SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA. severe acute respiratory syndrome Coronavirus simple Spread target targets [DOI] 10.1016/j.aca.2022.339846 PMC 바로가기 [Article Type] Article
Molnupiravir; molecular and functional descriptors of mitochondrial safety몰누피라비르; 미토콘드리아 안전성의 분자 및 기능 설명자Article Published on 2022-05-012022-09-11 Journal: Toxicology and applied pharmacology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] active form Adult patients Analyzer antiviral drug antiviral drugs approved arrest cell line Concentration concentrations copy number COVID-19 Culture cytotoxicity DNA polymerase dose drug emergency treatment Endpoint expression flux functional Genome HepG2 HepG2 cell incorporation inhibit lack mechanism metabolite Mitochondria mitochondrial mitochondrial DNA Mitochondrial function mitochondrial gene molecular molnupiravir molnupiravir. Mutation N-hydroxycytidine NHC nucleoside Patient phenotypic PolG POLRMT progression RdRP replicating virus Replication resulting risk RNA polymerase significantly specificity the SARS-CoV-2 Toxicity Transcription Treatment triphosphate U.S. FDA viral genome virus was measured [DOI] 10.1016/j.taap.2022.116003 PMC 바로가기 [Article Type] Article
The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus ParticlesSARS-CoV-2 스파이크 단백질의 "LLQY" 모티프는 S가 바이러스 입자에 통합되는 데 영향을 줍니다.Article Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alter Amino acid amino acid residue amino acids antiviral drug antiviral drugs assembly biological significance Biosynthesis caused Cell culture cleavage cleavage site cleavage sites cleaved conformational conservation conserved Contact contribute coronavirus COVID-19 epidemic Critical demonstrated Effectiveness expressed glycoprotein hydrogen Hydrogen bond hydrogen bonds incorporation Infection intrachain junction key amino acid key amino acids less Lineage LLQY domain membrane fusion motif mutated Mutation Neutralizing antibodies Particle Prevent processing producer cell protease Protein protein synthesis protein synthesis and cleavage Pseudotyped virus pseudovirus pseudovirus pseudoviruses reduce residue S protein S1/S2 SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability subcellular localization synthesis the S protein the SARS-CoV-2 Transmission tyrosine Vaccines viral entry viral infection virus virus assembly. Virus-like particle virus-like particles [DOI] 10.1128/jvi.01897-21 PMC 바로가기 [Article Type] Article